HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma
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چکیده
منابع مشابه
HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.
Chromosomal rearrangements of the RET proto-oncogene (RET/PTC) are the common feature of papillary thyroid carcinoma (PTC). In this study, we report the identification, cloning, and functional characterization of a novel type of RET/PTC rearrangement that results from the fusion of the 3'-portion of RET coding for the tyrosine kinase (TK) domain of the receptor to the 5'-portion of the Homo sap...
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PURPOSE Papillary thyroid carcinomas (PTC) are the most common type of thyroid malignancy with one of the two mutations, RET/PTC rearrangement or BRAF mutation. Both mutations are able to activate the MEK/ERK signaling transduction pathway and result in the activation of transcription factors that regulate cellular proliferation, differentiation, and apoptosis. Sorafenib (Nexavar, BAY 43-9006) ...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2007
ISSN: 1351-0088,1479-6821
DOI: 10.1677/erc-07-0039